We had people report a corrupted save file issue during the transition from 1.0.3 to 1.0.4, try running your patcher.exe, apply the new patch and run your game from the patcher 
Backup your saves, don't lose progress!
C:\users\<Username>\Saved Games\Pokemon_Uranium
Save Backups:
C:\users\<Username>\Saved Games\Pokemon_Uranium\Backups
C:\users\<Username>\Saved Games\Pokemon_Uranium
Save Backups:
C:\users\<Username>\Saved Games\Pokemon_Uranium\Backups
OID: 000003 OT: Cody
